Small-Pool High-Yield Factor VIII Production
作者： Cees Th. Smit Sibinga
DOI: 10.3109/10408368609111596
关键词:
摘要: Hemophilia care depends on several factors for the production of purified FVIII: plasma procurement, logistics, method, and efficacy. The latter two are restrictive factors, both supply safety FVIII preparations. Conventional methodology unavoidably recovers only 10 to 20% usable protein, therefore requiring large pools source plasma. Related pool size is transmission diseases, which poses unnecessary risks patients. development new technologies better recover allows reduction size: crush-thaw, controlled pore-glass chromatography, heparin double-cold precipitation techniques. This review will reflect current methods, concept, small-pool approaches in production, future developments.
informapharmascience.com参考文章(81)
P. R. Foster, A. J. Dickson, Control of Large-Scale Plasma Thawing Plasma Fractionation and Blood Transfusion. pp. 57- 65 ,(1985) , 10.1007/978-1-4613-2631-1_8
S. Middleton, Polyelectrolytes and preparation of Factor VIIIC Springer Netherlands. pp. 109- 120 ,(1982) , 10.1007/978-94-011-9764-9_10
R. J. Gerety, Prevention of Transmission of Virus Infections by Blood Transfusions and Removal of Virus Infectivity from Clotting Factor Concentrates Plasma Fractionation and Blood Transfusion. pp. 143- 146 ,(1985) , 10.1007/978-1-4613-2631-1_18
A Krachmalnicoff, D P Thomas, The stability of factor VIII in heparinized plasma. Thrombosis and Haemostasis. ,vol. 49, pp. 224- 227 ,(1983) , 10.1055/S-0038-1657367
J. Over, M. P. J. Piët, J. A. Loos, H. P. J. Henrichs, P. J. Hoek, M. A. von Meyenfeldt, J. I. H. Oh, Contributions to the Optimization of Factor VIII Production: Cryoprecipitation and Controlled Pore Glass Adsorption Plasma Fractionation and Blood Transfusion. pp. 67- 78 ,(1985) , 10.1007/978-1-4613-2631-1_9
C. V. Prowse, Donation Procedure: Collection Lesion, Fibrinopeptide A, and Factor VIII Plasma Fractionation and Blood Transfusion. pp. 25- 32 ,(1985) , 10.1007/978-1-4613-2631-1_4
Smit Sibinga C, Britten A, Etzel F, Carman C, Ala F, Supply and need of factor VIII concentrates. Haematologia. ,vol. 16, pp. 109- ,(1983)
J. K. Smith, D. R. Evans, Processing Criteria for Recovery of FFP for Fractionation Plasma Fractionation and Blood Transfusion. pp. 15- 23 ,(1985) , 10.1007/978-1-4613-2631-1_3
J. M. Curling, Methods of plasma protein fractionation Academic Press. ,(1980)
F. Feldman, New Developments in F VIII Purification, an Overview Springer, Dordrecht. pp. 249- 263 ,(1982) , 10.1007/978-94-009-7692-4_24