Influence of ATP-sensitive potassium channel modulators on ischemia-induced fibrillation in isolated rat hearts
作者： Charles D Wolleben , Michael C Sanguinetti , Peter KS Siegl
DOI: 10.1016/0022-2828(89)90717-7
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摘要: Abstract We have confirmed the findings of Kantor and colleagues that ischemia-induced fibrillation in isolated Langendorff-perfused rat hearts can be prevented by glyburide, a blocker ATP-dependent K channels. These data suggest block current [ I K(ATP) ] is novel antiarrhythmic mechanism. This hypothesis was further tested evaluating effects another sulfonylurea blocker, tolbutamide (1 m ) two agents known to activate these channels cardiac tissue, BRL 34915 (10 μ pinacidil (30 ). Similar also effective preventing this heart model. The activators enhanced rate tachycardia shortened time required for develop fibrillation. Coadministration glyburide with either activator their effects. It concluded activation during global ischemia contributes development perfused
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