Crystalline form of tiotropium bromide with lactose

摘要: A cocrystal of tiotropium bromide and lactose monohydrate is herein disclosed. In the components are preferably present in an almost stoichiometric ratio. Said has a single endothermic event at about 191-3°C determined by DSC. process for preparation also Preferably, particle size distribution D90 < 10µ. The disclosed use as medicament, particular treatment respiratory complaint, such chronic obstructive pulmonary disease (COPD), bronchitis, emphysema asthma. pharmaceutical composition comprising active ingredient disclosed, administration inhalation. latter case, said mean 0.5 to 10 µm, 1 6 more 1.5 5 µm.