Crystalline anticholinergic, processes for preparing it and its use for preparing a pharmaceutical composition

作者: Ulrike Werthmann , Peter Sieger

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摘要: The invention relates to crystalline, water-free (1.alpha.,2.beta.,4.beta.,5.alpha.,7.beta.-7-[(hydroxydi-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo [3.3.1.02,4] nonane-bromide, a method for its production, and the use thereof in production of drug, especially an anticholinergic drug.

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Peter J Barnes, Maria G Belvisi, Judith C.W. Mak, El-Bdaoui Haddad, Brian O'Connor, Tiotropium bromide (Ba 679 BR), a novel long-acting muscarinic antagonist for the treatment of obstructive airways disease. Life Sciences. ,vol. 56, pp. 853- 859 ,(1995) , 10.1016/0024-3205(95)00020-7
Peter Specht, Helmut Meissner, Andreas Mathes, Wolfgang Broeder, Sven Luettke, Manfred Graulich, Rolf Banholzer, Method for producing the anticholinergic agent tiotropium bromide ,(2001)