Diurnal variation in the responsiveness of human subjects to human growth hormone.
作者： Daniel Rudman , David Freides , Joseph H. Patterson , Donna L. Gibbas
DOI: 10.1172/JCI107256
关键词:
摘要: The objective of this study was to compare the responsiveness human subjects anabolic effects growth hormone (HGH) administered at 8 a.m. or 11 p.m. Three doses HGH were used: A, 0.0168 U/kg body weight (BW)(3/4) per day; B, 0.0532 BW(3/4) C, 0.168 day. effect each dose on daily balances N, P, Na, and K BW measured. two groups: (a) seven GH-deficient children, whom three deficient in ACTH; (b) patients with limb-girdle dystrophy. ACTH-deficient group received exogenous cortisol 7 In all 10 subjects, sometimes B significantly (P < 0.05) greater than when these experiments plasma concentration averaged 3 times next experiments, injected vs. again compared. Under conditions, a.m., caused responses These findings indicate that magnitude response is inversely related time injection.
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