Modelo predictivo de fragmentación de ADN espermático usando parámetros evaluados en un espermatograma

摘要: Introduction: The spermatogram is used as a test of seminal quality. Recently, the sperm fragmentation has demonstrated importance DNA integrity would affect clinical results in assisted reproduction treatments. Objectives: To determine variables that independently predict index (SFI). Design: Retrospective, comparative study. Settings: Grupo PRANOR, Reprogenetics Latinoamerica, Clinica Concebir, Lima, Peru. Biologic material: Sperm. Methods: Individual and two models were compared: first model considered percentage viability patient’s age; second included motile sperms age. Logistic regression analysis was done. Main outcome measures: Sperm viability, Results: Multivariate showed both significantly superior to individuals (p<0.01). had non standardized coefficient values (95%CI) respectively 0.200 (0.082 0.318) -0.146 (-0.206 -0.086). -0.099 (-0.157 -0.042) 0.219 (0.99 0.339). age predicted probability having an SFI over 30% with 95%IC 0.034 (0.015 0.053) -0.043 (0.034 0.052). Additionally 95%CI -0.04 (-0.031 -0.049) 0.035 (0.017 0.053). Finally, ROC curve superiority some individual areas under (ABC) 1 (age viability) 0.727 (95%CI = 0.665 0.790) 2 total motility) 0.675 0.606 0.744), compared ABC 0.295 0.229 0.362), motility 0.333 0.264 0.403) 0.584 0.510 0.658). Conclusions: Age, correlated consequently these could be predictors percentage.