Sperm DNA damage: correlation to severity of semen abnormalities.

作者: Sergey I. Moskovtsev , Jennifer Willis , John White , J. Brendan M. Mullen

DOI: 10.1016/J.UROLOGY.2009.05.043

关键词:

摘要: OBJECTIVES To analyze the relationship between DNA damage and standard semen parameters (SSP) in patients who present for fertility evaluation. Evaluation of male includes assessment SSP increasingly sperm damage. However, remains controversial. METHODS Following Institutional Research Ethics Board approval, samples from 2586 unselected nonazoospermic were subjected to computer-assisted analysis flow cytometry-based expressed as fragmentation index. RESULTS Sperm was significantly negatively correlated (concentration, motility, normal morphology) positively patient's age. increased association with number abnormalities SSP. Patients oligoasthenoteratozoospermia had higher more frequent over 30% compared normozoospermic 1 or 2 CONCLUSIONS Our results indicate that is well In addition, degree increases abnormal a sample most severe oligoasthenoteratozoospermia. Complex possibly age-related mechanisms human spermatozoa may be responsible strong

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