摘要: The genus Aspergillus of ascomycete fungi comprises about 200 species. Some these species reproduce sexually. Aspergilli produce noxious toxins, and some are pathogens. Invasive aspergillosis is a serious concern as it frequently affects immunodepressed patients. have multiple biotechnological uses, from traditional fermentation procedures to production recombinant proteins. One species, (Emericella) nidulans, has been used investigate fundamental problems biology. Investigations using this model system led the unraveling nitrogen carbon metabolite repression, pH regulation, secondary regulation identification genes mutated in human metabolic diseases. comparison structures A. nidulans mitochondrial introns account for intron self-splicing. Work on cell cycle discovery γ-tubulin proteins involved entry or exit mitosis nuclear movement. Active research an understanding conidiophore development, septation mycelia, establishment polarity. Finally, availability eight different genomes contributes evolution sex fungi, new metabolites, possible targets antifungal agents.
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