Chewing gum to treat postoperative nausea and emesis in female patients (CHEWY): rationale and design for a multicentre randomised trial.

摘要: Introduction Postoperative nausea, retching and vomiting (PONV) remains one of the most common side effects general anaesthesia, contributing significantly to patient dissatisfaction, cost complications. Chewing gum has potential as a novel, drug-free alternative treatment. We aim conduct large, definitive randomised controlled trial efficacy safety peppermint-flavoured chewing treat PONV in postanaesthesia care unit (PACU). If is shown be effective ondansetron, this improve outcomes for tens millions surgical patients around world each year. Methods analysis This prospective, multicentre, non-inferiority trial. 272 female aged ≥12 years having volatile anaesthetic-based anaesthesia breast or laparoscopic surgery will randomised. Patients experiencing PACU 15 min 4 mg intravenous ondansetron. The primary outcome (complete response) cessation within 2 hours administration, with no recurrence nor rescue medication requirement after administration. Ethics dissemination Chewy Trial been approved by Human Research Committees at all sites. Dissemination via international national conferences, publication peer-reviewed literature. registration number ACTRN12618000429257; Pre-results.