MRI Features Can Predict 1p/19q Status in Intracranial Gliomas

摘要: BACKGROUND AND PURPOSE: The 2016 revision of the World Health Organization Classification Tumors Central Nervous System mandates codeletion chromosomes 1p and 19q for diagnosis oligodendroglioma. We studied whether conventional MR imaging features could predict 1p/19q status. MATERIALS METHODS: Patients with previous testing were identified through pathology department records, typically performed on basis an oligodendroglial component routine histology; 69 patients met inclusion criteria. Preoperative grade II or III gliomas was retrospectively assessed by 2 neuroradiologists, blinded to Thirteen first in a small initial cohort ( n = 10), after which criteria narrowed remaining as validation cohort. RESULTS: There 85% agreement between radiologists overall prediction status cohort, accuracy 84%. presence >50% T2-FLAIR mismatch calcification found be most useful predicting variable demonstrated 14 tumors had 100% specificity identifying noncodeleted tumor P .001), 97% interobserver correlation. Calcification visualized 7 tumors, 6 codeleted (specificity, 97%; .006), CONCLUSIONS: is highly predictive tumor, while calcifications suggest tumor. If formal not possible, combined imaging–histologic assessment may improve diagnostic over histology alone.