MRI grading versus histology: predicting survival of World Health Organization grade II-IV astrocytomas.

摘要: BACKGROUND AND PURPOSE: Histologic grading of intracranial astrocytomas is affected by sampling error and substantial inter- intraobserver variability. We proposed that incorporating MR imaging into will predict patient survival more accurately than histopathology alone. MATERIALS METHODS: Patients with a new diagnosis World Health Organization grades II–IV astrocytoma or mixed oligoastrocytoma diagnosed between September 2007 December 2010 were identified. Two hundred forty-five patients met the inclusion criteria. Preoperative MRIs independently reviewed 2 readers blinded to histologic grade, an grade was given. The histopathologic compared survival. RESULTS: II III on histology but evidence necrosis (consistent IV tumor) had significantly worse same no ( P = .002 for .029 III). Their not different from in tumors .164 .385, respectively); this outcome suggests all most are likely have truly been tumors. less frequent oligoastrocytomas, preventing adequate subgroup analysis. CONCLUSIONS: can improve identifying suspected being undergraded histology, high interobserver agreement. This finding has potential optimize management, example, encouraging aggressive treatment earlier patient9s course.