Preoperative relative cerebral blood volume analysis in gliomas predicts survival and mitigates risk of biopsy sampling error

摘要: Appropriate management of adult gliomas requires an accurate histopathological diagnosis. However, the heterogeneity can lead to misdiagnosis and undergrading, especially with biopsy. We evaluated role preoperative relative cerebral blood volume (rCBV) analysis in conjunction as a predictor overall survival risk undergrading. retrospectively identified 146 patients newly diagnosed (WHO grade II–IV) that had undergone MRI rCBV analysis. compared by histopathologically determined WHO tumor using Kaplan–Meier curves Cox proportional hazards model. also imaging findings initial diagnosis 13 who underwent biopsy followed subsequent resection. Survival tier similarly separated into low, intermediate, high-risk groups shorter corresponding higher or tier. The hazard ratio for III versus II was 3.91 (p = 0.018) IV 11.26 < 0.0001) each increase 1.0 units 1.12 0.002). Additionally, 3 (23%) initially were upgraded on Preoperative elevated at least one standard deviation above mean patients, suggestive but not ten concordant diagnoses. In conclusion, predict pathologically gliomas. Discordant histopathology may help identify