Multi-antigenic vaccine against the cattle tick Rhipicephalus (Boophilus) microplus: a field evaluation.

摘要: The tick Rhipicephalus (Boophilus) microplus is a blood-sucking ectoparasite of cattle that severely impairs livestock production. Studies on immunological control address mostly single-antigen vaccines. However, from the commercial standpoint, so far no vaccine has afforded appropriate protection against all R. populations. In this context, multi-antigen cocktails have emerged as way to enhance efficacy. work, multi-antigenic was analyzed under field conditions in naturally infested cattle. composed by three recombinant proteins two species previous single-vaccination reports provided partial confined infestations: vitellin-degrading cysteine endopeptidase (VTDCE) and boophilus yolk pro-cathepsin (BYC) microplus, glutathione S-transferase Haemaphysalis longicornis (GST-Hl). Increased antibody levels were recorded after immunizations, with distinct humoral immune response dynamics for each protein. Compared group, statistically significant lower number semi-engorged female ticks observed vaccinated inoculations. This reduction persisted 3 months, ranging 35.3 61.6%. Furthermore, body weight gain significantly higher animals when compared vaccines VTDCE, BYC or GST-Hl, three-antigen infestations.