Inhibition of glutathione metabolism attenuates esophageal cancer progression.

摘要: Esophageal squamous cell carcinoma (ESCC) is a deadly malignancy with regard to mortality and prognosis, the 5-year survival rate for all patients diagnosed ESCC remains poor. A better understanding of biological mechanisms tumorigenesis progression great importance improve treatment this disease. In study, we demonstrated that glutathione metabolism pathway highly enriched in cells compared normal esophageal epithelial an vivo mouse model. addition, L-buthionine-sulfoximine (BSO) deplete decreased tumor burden mice, thus demonstrating critical role progression. BSO also led proliferation activation apoptosis ESCC. Finally, blocked NF-kB Our study reveals new regulates suggests inhibition may be potential strategy treatment.