Glutathione-S-transferases M1 (GSTM1) and GSTT1 genotype, smoking, consumption of alcohol and tea and risk of esophageal and stomach cancers : a case-control study of a high-incidence area in Jiangsu Province, China
作者： Chang-Ming Gao , Toshiro Takezaki , Jian-Zhong Wu , Zhong-You Li , Yan-Ting Liu
DOI: 10.1016/S0304-3835(02)00115-5
关键词:
摘要: To evaluate interactions between lifestyle factors and glutathione-S-transferases M1 (GSTM1) GSTT1 genotypes with reference to development of esophageal stomach cancers, we conducted a case-control study 141 cases cancer, 153 cancer 223 population-based controls in Huaian City Jiangsu Province, China. GSTM1 were identified by multiplex polymerase chain reaction. The null genotype was associated an increased odds ratio for (2.17, 95% confidence interval=1.35-3.50), but not cancer. A combined effect also observed smoking the regard risk. Tea drinking protective factor both its being independent genotypes. These findings suggest polymorphism is involved susceptibility development, tea consumption reduces risk cancers.
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