GSTM1 null genotype and gastric cancer risk in the Chinese population: an updated meta-analysis and review.

摘要: Although a number of studies have been conducted on the association between GSTM1 null genotype and gastric cancer in People’s Republic China, this remains elusive controversial. To clarify effects risk cancer, an updated meta-analysis was performed Chinese population. Related were identified from PubMed, Springer Link, Ovid, Wanfang Data Knowledge Service Platform, National Infrastructure (CNKI), Biology Medicine (CBM) up to November 5, 2014. A total 25 including 3,491 cases 5,921 controls included meta-analysis. Overall, significant (odds ratio [OR] =1.47, 95% CI: 1.28–1.69) found when all population pooled into In subgroup analyses stratified by quality score, geographic area, source controls, same results observed. Additionally, both smokers non-smokers. This showed that may be potential biomarker for Chinese, further with gene–gene gene–environment interactions are required definite conclusions.