Interaction models of CYP1A1, GSTM1 polymorphisms and tobacco smoking in intestinal gastric cancer

摘要: AIM: To explore the interaction models of cytochrome P-450 (CYP) 1A1 Val variant and glutathione S-transferase (GST) M1 null polymorphisms with tobacco smoking in occurrence intestinal gastric cancer. METHODS: A community-based case-control study was conducted Yangzhong. Subjects included 114 types cancer endoscopic pathological diagnosis during January 1997 December 1998, 693 controls selected from their spouse, siblings or siblings-in-law who had no history digestive system cancer. Logistic regression used to estimate models. RESULTS: The frequency CYP1A1 allele cases did not differ that controls. OR GSTM1 genotype 2.0 (95% confidence interval [95%CI]: 1.2-3.1, P<0.01). It showed a significant type 2 form model when both Valvariant former existed (i.e., among multiplicative effects, disease risk is increased by exposure alone but alone). index g 2.8, OReg(95%CI) 5.0 (1.9-13.4). were 4 effects). OReg (95%CI) 3.4 8.4 (3.4-20.9), respectively. CONCLUSION: Different will contribute understanding carcinogenic mechanism, there need further investigate larger scale studies.