Mild Propofol Sedation Reduces Frontal Lobe and Thalamic Cerebral Blood Flow: An Arterial Spin Labeling Study.

摘要: Mechanisms of anesthetic drug-induced sedation and unconsciousness are still incompletely understood. Functional neuroimaging modalities provide a window to study brain function changes during anesthesia allowing us explore the sequence neuro-physiological associated with anesthesia. Cerebral perfusion change under an assumption intact neurovascular coupling is indicator in large-scale neural activity. In this experiment, we have investigated resting state cerebral blood flow (CBF) human mild sedation, propofol. Arterial spin labeling (ASL) provides non-invasive, reliable, robust means measuring can therefore be used investigate central drug effects. Mild propofol sedation-related CBF were studied at rest (n = 15), 3 T MR scanner using PICORE-QUIPSS II ASL technique. was reduced bilateral paracingulate cortex, premotor Broca’s areas, right superior frontal gyrus also thalamus. This demonstrates that induces suppression key cortical (frontal lobe) subcortical (thalamus) regions sedation.