Reduced Dynamic Coupling Between Spontaneous BOLD-CBF Fluctuations in Older Adults: A Dual-Echo pCASL Study.

摘要: Measurement of the dynamic coupling between spontaneous Blood Oxygenation Level Dependent (BOLD) and cerebral blood flow (CBF) fluctuations has been recently proposed as a method to probe resting-state brain physiology. Here we investigated how BOLD-CBF during is affected by aging. Fifteen young subjects 17 healthy elderlies were studied using dual-echo pCASL sequence. We found that was markedly reduced in elderlies, particular left supramarginal gyrus, an area known be involved verbal working memory episodic memory. Moreover, correcting for temporal shift BOLD CBF timecourses resulted increased correlation two signals both groups, but with larger increase elderlies. However, even after correction, significantly decreased still observed indicating age-related uncoupling this region more pronounced can only partially explained simple time-shift signals. Interestingly, these results group normal cognitive functions, suggesting study promising technique, potentially able provide early biomarkers functional changes aging brain.