The relevance of serum vitamin D in psoriasis: a review.

摘要: Observational research has identified low serum levels of 25-hydroxyvitamin D (25[OH]D) in many non-skeletal diseases. Whether this is causal or due to underlying illness unknown. Low 25[OH]D are also reported the general population. and experimental studies identify that vitamin supplementation may be beneficial reducing all-cause mortality elderly women, as well cancer mortality. Our aim was review literature relevance psoriasis. Forty-five were included our analysis. Most these psoriasis patients. Evidence causality lacking. Treatment with phototherapy leads an increase 25[OH]D. There little evidence after correlates improved disease severity. Multiple report improvement supplementation. These data predominantly from small observational non-randomised interventional studies. Randomised controlled trials date have had numbers short follow-up periods. The optimal dose unknown dosing not standardised across different definition insufficiency varies associated comorbidities patients, including metabolic syndrome cardiovascular risk. causation absent. Until further high-quality available, patients unknown, benefit on control. Supplementation those at risk impaired bone health.