Concurrent infections are important for expression of porcine circovirus associated disease

摘要: Porcine circovirus type 2 (PCV2) is the essential component of porcine disease (PCVD) as syndrome referred to in Europe and associated (PCVAD) it North America. Singular PCV2 infection rarely results clinical disease; however, PCVAD often accelerated onset, enhanced severity prolonged duration by concurrent viral or bacterial infections. Due its effect on immune system, has also been shown enhance protozoal, metazoal, fungal Several retrospective cross-sectional studies have investigated presence prevalence various infectious agents with under field conditions. Experimental models confirm that replication lesions can be other viruses bacteria. The exact mechanisms which pathogens upregulate are unknown. Co-infections may promote increasing host cell accumulation tissues thereby enhancing targets for replication. It proposed co-infections interfere clearance alteration cytokine production profiles. outcome differences timing PCV2-infected pigs likely very important an area where more research needed. Given current knowledge base, veterinarians do a thorough diagnostic investigation herds recurrent problem order implement most appropriate cost effective intervention strategies.