Magnetic resonance imaging–determined synovial membrane volume as a marker of disease activity and a predictor of progressive joint destruction in the wrists of patients with rheumatoid arthritis

摘要: Objective To evaluate the synovial membrane volume, determined by magnetic resonance imaging (MRI), as a marker of joint disease activity and predictor progressive destruction in rheumatoid arthritis (RA). Methods Twenty-six patients with RA, randomized to receive disease-modifying antirheumatic drug (DMARD) therapy alone (11 patients) or DMARDs combination oral prednisolone (15 patients), were followed up for 1 year contrast-enhanced MRI dominant wrist (months 0, 3, 6, 12), conventional radiography 0 clinical biochemical examinations. Bone erosion (by radiography) volumes MRI) assessed. Results Significant volume reductions observed after 3 6 months DMARD + group, 12 DMARD-alone group (P < 0.01–0.02, Wilcoxon-Pratt analysis). The rate erosive progression on was highly correlated baseline scores and, particularly, area under curve (AUC) values (Spearman's σ = 0.69, P 0.001), but not AUC local global parameters, treatment. In none 5 wrists <5 cm3, 8 10 ≥10 found and/or radiography, indicating predictive value volumes. more sensitive than detection bone (22 versus new erosions). Conclusion MRI-determined are closely related destruction. Quantitative assessment synovitis may prove valuable RA.