Antimicrobial resistance in the respiratory microbiota of people with cystic fibrosis

摘要: Cystic fibrosis is characterised by chronic polymicrobial infection and inflammation in the airways of patients. Antibiotic treatment regimens, targeting recognised pathogens, have substantially contributed to increased life expectancy patients with this disease. Although emergence antimicrobial resistance selection highly antibiotic-resistant bacterial strains major concern, clinical relevance cystic yet be defined. Resistance has been identified pathogens other bacteria (eg, Prevotella Streptococcus spp) detected airway microbiota, but their role pathophysiology lung disease unclear. Increased antibiotic might attributed a range complex factors including horizontal gene transfer, hypoxia, biofilm formation. Strategies manage consist new antibiotics or localised delivery agents, iron sequestration, inhibition quorum-sensing, resistome analysis. Determination contributions every species health also an important management resistance.