Immune response against dying tumor cells.

摘要: Publisher Summary This chapter provides clear evidence in favor of tumor escape mechanisms. Melanomas from patients experiencing partial responses after T-cell–based immunotherapies reportedly lose β 2 -microglobulin expression or down modulate the target antigen. The central dilemma cancer immunotherapy resides striking contrast between lack spontaneous antitumor immune and apparent possibility to induce active experimentally. Irradiation chemotherapy mostly a type cell death, apoptosis that is widely thought be immunologically silent even tolerogenic. Thus, paradoxically, standard treatments are used clinical management both solid diffuse tumors would suppress any patient's system eradicates those residual cells will ultimately cause relapse. examines this hypothetical scenario way modality death and/or can manipulated so dying become immunogenic. Antitumor induced by vaccination providing formulation concentrated antigens whose optimal presentation ensured vitro vivo application suitable immunostimulatory agents. Most studies performed concentrate on dichotomy necrosis incurring important methodological problems discussed chapter.