Active efflux of daunorubicin and adriamycin in sensitive and resistant sublines of P388 leukemia.
作者： Randall K. Johnson , Makoto Inaba , Yoshio Sakurai , Harumi Kobayashi
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摘要: Significantly decreased uptake and retention of daunorubicin (DAU) Adriamycin (ADR) have been reported in sublines P388 leukemia resistant to these anthracyclines. We studied the effects inhibitors oxidative phosphorylation on DAU ADR order characterize transport process for anthracyclines clarify further alteration cells. In glucose-free medium, was accelerated by metabolic a greater extent cells than sensitive Under conditions, drug similar When glucose added incubation medium presence 2,4-dinitrophenol, efflux from both observed. Net also observed with cells, whereas markedly inhibited 2,4-dinitrophenol-stimulated Furthermore, preloaded DAU, drugs addition 2,4-dinitrophenol. These results suggest that there is an active outward mechanism enhanced activity this renders highly cytostatic cytotoxic DAU.
aacrjournals.org参考文章(3)
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