The mitogenic activity of type III bacterial Ig binding proteins (protein G) for human peripheral blood lymphocytes is not related to their ability to react with human serum albumin or IgG.

摘要: The mitogenic potential of bacterial IgG Fc binding proteins for human PBL is controversial. Wild type and recombinant III induce a wide spectrum proliferative responses ranging from non-mitogenic to potent responses. To understand the reason these differences, three forms protein derived single group C streptococcal strain, 26RP66, were generated. Form I bound serum albumin, form II alone albumin alone. These functionally distinct compared with corresponding wild preparation same strain potential. A response was induced only or native protein. shared functional characteristics IgG. Mixtures (form II) fragments III) failed reconstitute full length proteins. results demonstrate that has not related its ability react