Assessment of Cpa, Scl1 and Scl2 in clinical group A streptococcus isolates and patients from north India: an evaluation of the host pathogen interaction.
作者： Priyanka Chaudhary , Rajesh Kumar , Vivek Sagar , Subendu Sarkar , Rupneet Singh
DOI: 10.1016/J.RESMIC.2017.09.002
关键词:
摘要: Abstract Group A streptococcus (GAS) infection remains a major concern due to multiple diseases including pharyngitis, impetigo, acute rheumatic fever (ARF) and heart disease (RHD). It uses different adhesins virulence factors like Cpa (collagen binding protein) Scl (collagen-like in its pathogenicity. having similarities with human collagen may contribute inducing autoimmunity the host. Here we assessed gene expression, antibody titer of Cpa, Scl1 Scl2 both clinical GAS isolates (n = 45) blood obtained from ARF (acute fever) RHD respectively. Skin (n = 30) were impetigo patients. The study revealed total 27 emm types. Frequency cpa, scl1, scl2 was high isolates. these proteins all isolates, also patients pharyngitis ARF. All showed affinity toward I IV, which further indicates potential host pathogen interaction. Our reflects strong association Scls early post-GAS However, increased during be attributed cogent immune response
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