Multiple viral/self immunological cross-reactivity in liver kidney microsomal antibody positive hepatitis C virus infected patients is associated with the possession of HLA B51.
作者： D.-P. Bogdanos , M. Lenzi , M. Okamoto , E. I. Rigopoulou , P. Muratori
DOI: 10.1177/039463200401700112
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摘要: Liver Kidney Microsomal autoantibody type 1(LKM1) directed to cytochrome P4502D6 (CYP2D6) characterises autoimmune hepatitis type-2 (AIH-2), but is also found in a proportion of chronic C virus (HCV) infected patients, CYP2D6252-271 being major B- cell autoepitope. Molecular mimicry and immunological cross-reactivity between CYP2D6252-271, HCV polyprotein the protein 4 (ICP4) herpes simplex 1 (HSV-1) have been suggested as triggers for induction LKM1, reactivity relevant sequences not investigated experimentally. its viral homologues were constructed tested by ELISA sera 46 chronically 23 whom LKM1 positive. Reactivity E1 ICP4 HSV1 mimics was frequently patients irrespectively their status; viral/self (as indicated inhibition studies), however, present only 2 seropositive who possessed HLA allotype B51. Our results indicate that virus/self dependent on specific immunogenetic background, finding awaiting confirmation studies larger series patients.
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