Action of various antidepressant treatments reduces reactivity of noradrenergic cyclic AMP-generating system in limbic forebrain.

摘要: STUDIES on the pharmacology of noradrenergic cyclic AMP-generating system in slices from limbic forebrain rat1 and adaptive properties this conditions persistent changes availability nor-adrenaline (NA) have revealed that may serve as a model for central NA receptor area, its sensitivity to increases or decreases when at site respectively2,3. Thus, hypersensitivity has been achieved by treatment with reserpine2, drug known precipitate occasionally severe depressive reactions man4, syndrome which, elicited animals, is widely used depression5–7. Conversely, monoamine oxidase (MAO) inhibitors, pargyline nialamide, caused marked reduction reactivity after chronic administration3. To determine whether not antidepressant drugs which do elevate level monoamines brain share effect MAO inhibitors system, we studied tricyclic antidepressants, desipramine iprindole, NA. Desipramine blocks uptake through neuronal membrane8,9 whereas iprindole neither nor alters metabolism turnover10,11, but nevertheless potent antidepressant12–14. In addition, tested electroconvulsive (ECT), it generally accepted be one most effective treatments depression15.