H2AX: the histone guardian of the genome.

摘要: At close hand to one's genomic material are the histones that make up nucleosome. Standing guard, one variant stays hidden doubling as of core histones. But, thanks its prime positioning, a variation in tail H2AX enables rapid modification histone code response DNA damage. A role for phosphorylation has been demonstrated repair, cell cycle checkpoints, regulated gene recombination events, and tumor suppression. In this review, we summarize what have learned about marker breaks, highlight some questions remain be elucidated physiological H2AX. We also suggest model which chromatin restructuring mediated by serves concentrate repair/signaling factors and/or tether ends together, could explain pleotropic phenotypes observed absence.