Sox5 Is a DNA-binding cofactor for BMP R-Smads that directs target specificity during patterning of the early ectoderm.

摘要: The SoxD factor, Sox5, is expressed in ectodermal cells at times and places where BMP signaling active, including the of animal hemisphere blastula stages neural plate border crest neurula stages. Sox5 required for proper ectoderm development, deficient embryos display patterning defects characteristic perturbations signaling, loss epidermis expansion plate. We show that essential activation target genes explants, it physically interacts with R-Smads, recruitment Smad1/4 to regulatory elements. Our findings identify as long-sought DNA-binding partner R-Smads plasticity pattern early ectoderm.