2-(Nitroaryl)benzothiazole and benzoxazole derivatives as fluorogenic substrates for the detection of nitroreductase activity in clinically important microorganisms.

作者: Marie Cellier , Amandine Gignoux , Arthur L. James , Sylvain Orenga , John D. Perry

DOI: 10.1016/J.BMCL.2015.10.099

关键词:

摘要: A series of carboxy-substituted 2-(nitroaryl)benzothiazole derivatives and 2-(nitroaryl)benzoxazole were prepared evaluated as potential nitroreductase substrates for the purpose detecting clinically important microorganisms. Several produced highly fluorescent colonies with majority a panel 10 Gram-negative bacteria also two 8 Gram-positive bacteria.

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