Saccharin mechanistic data and risk assessment: Urine composition, enhanced cell proliferation, and tumor promotion
作者： John Whysner , Gary M. Williams
DOI: 10.1016/0163-7258(96)00069-1
关键词:
摘要: Sodium saccharin (NaSac) produces bladder tumors consistently in male rats only after lifetime exposure that begins at birth. NaSac is not metabolized and negative most genotoxicity tests. NaSac-induced cell damage proliferation have been proposed as important factors tumor promotion, dose-response information demonstrating a threshold for these parameters available. One theory proposes high levels of NaSac, combined with protein Na+, pH environment found the rat, form toxic microscopic crystals; therefore, may be relevant to human carcinogenesis.
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