Regulation of the Actin Cytoskeleton by Inositol Phospholipid Pathways

摘要: Changes in the actin cytoskeleton are a fundamental part of motile response cells to extracellular ligands. Dynamic alterations both structural and biochemical properties network mediate changes cell shape migration (Cooper, 1991; Gips et al., 1994). This meshwork microfilaments is responsible for many characteristic intracellular structures, including stress fibers, cortical network, contractile rings. Actin filament turnover, example, associated with formation microspikes lamellipodia at leading edge cells. In migrating cells, forward extension cellular lamellipodium, fan-shaped structure filled dense, cross-linked filaments, driven by polarized assembly monomers. not unique however, because it shares features other actin-based processes occurring beneath plasma membrane stimulated platelets, neutrophils, chemotactic amoebas, or even rear pathogenic bacterium Listeria monocytogenes during its propulsive movement through host cytoplasm (Theriot