Ras, superoxide and signal transduction.

摘要: This chapter provides information to Rac protein, superoxide, and signal transduction. GTP-binding proteins of the Ras superfamily regulate a wide variety cellular activities. The protein is member Rho branch this extended family. implicated in processes involved assembly actin cytoskeleton, stimulating formation lamellipodia membrane ruffles. In phagocytic cells, induces activation NADPH oxidase, leading free radical production, which key step for successful elimination infectious agents. intracellular pathways generation Reactive Oxygen Species (ROS) are best characterized these specialized cells. nonphagocytic also regulates production superoxide other reactive oxygen species, shown act as essential second messengers several cytokines growth factors. plants, resistance pathogens, such fungi, bacteria, viruses, depends on release ROS, termed oxidative burst. molecules play an important role defense mechanism against plant pathogens by regulating ROS. gene has been conserved throughout evolution, that its will ROS most cells can transduce pathway mammals well plants. concludes regulatory functions interaction with essential.