Antidepressant-like and anxiolytic-like actions of the mGlu5 receptor antagonist MTEP, microinjected into lateral septal nuclei of male Wistar rats.
作者： Miguel Molina-Hernández , Norma Patricia Tellez-Alcántara , Julián Pérez-García , Jorge Iván Olivera-Lopez , M. Teresa Jaramillo
DOI: 10.1016/J.PNPBP.2006.04.022
关键词:
摘要: This study describes the effects of intra-lateral septal infusions different doses mGluR5 antagonist MTEP in DRL-72 s paradigm and elevated plus-maze test rats, two behavioral models known to be sensitive antidepressant-like anxiolytic-like drug effects, respectively. Intra-lateral induced a dose-dependent (5.0 microg/microl, P<0.05; 10.0 P<0.05) increase reinforced lever presses cohesive rightward shift inter-response time distribution P<0.05). These are indicative actions compound. Desipramine, prototypical antidepressant drug, microg/microl; similar effects. In test, increased exploration open arms without affecting locomotion. effect was that observed with infusion benzodiazepine midazolam (10.0 same brain area. It is concluded mGlu5 receptor produced or male rats.
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sci-hub.se 参考文章(57)
Paul Willner, Richard Muscat, Animal Models for Investigating the Symptoms of Depression and the Mechanisms of Action of Antidepressant Drugs Animal Models in Psychopharmacology. pp. 183- 198 ,(1991) , 10.1007/978-3-0348-6419-0_16
Earl Thomas, Forebrain mechanisms in the relief of fear: The role of the lateral septum Psychobiology. ,vol. 16, pp. 36- 44 ,(1988) , 10.3758/BF03327297
Berend Olivier, Jef L. Slangen, J. Mos, Animal Models in Psychopharmacology ,(1991)
Textbook in psychiatric epidemiology Textbook in psychiatric epidemiology.. ,(2002) , 10.1002/0471234311
Ryuichi Shigemoto, Ayae Kinoshita, Eiki Wada, Sakashi Nomura, Hitoshi Ohishi, Masahiko Takada, Peter J. Flor, Akio Neki, Takaaki Abe, Shigetada Nakanishi, Noboru Mizuno, Differential presynaptic localization of metabotropic glutamate receptor subtypes in the rat hippocampus. The Journal of Neuroscience. ,vol. 17, pp. 7503- 7522 ,(1997) , 10.1523/JNEUROSCI.17-19-07503.1997
L S Seiden, G J Marek, A A Li, Evidence for involvement of 5-hydroxytryptamine1 receptors in antidepressant-like drug effects on differential-reinforcement-of-low-rate 72-second behavior. Journal of Pharmacology and Experimental Therapeutics. ,vol. 250, pp. 60- 71 ,(1989)
Robert M Goisman, Idell Goldenberg, Russell G Vasile, Martin B Keller, Comorbidity of anxiety disorders in a multicenter anxiety study Comprehensive Psychiatry. ,vol. 36, pp. 303- 311 ,(1995) , 10.1016/S0010-440X(95)90076-4
M Molina-Hernández, NP Tellez-Alcántara, J Pérez Garcı́a, JI Olivera Lopez, M Teresa Jaramillo, None, Anti-conflict-like actions of intralateral septal infusions of allopregnanolone in Wistar rats. Pharmacology, Biochemistry and Behavior. ,vol. 75, pp. 397- 404 ,(2003) , 10.1016/S0091-3057(03)00133-3
A Pilc, A Kłodzińska, P Brański, G Nowak, A Pałucha, B Szewczyk, E Tatarczyńska, E Chojnacka-Wójcik, J.M Wierońska, Multiple MPEP administrations evoke anxiolytic- and antidepressant-like effects in rats. Neuropharmacology. ,vol. 43, pp. 181- 187 ,(2002) , 10.1016/S0028-3908(02)00082-5
Elna Yadin, Earl Thomas, Holly L. Grishkat, Craig E. Strickland, The role of the lateral septum in anxiolysis. Physiology & Behavior. ,vol. 53, pp. 1077- 1083 ,(1993) , 10.1016/0031-9384(93)90362-J