Anti-conflict-like actions of intralateral septal infusions of allopregnanolone in Wistar rats.

作者: M Molina-Hernández , NP Tellez-Alcántara , J Pérez Garcı́a , JI Olivera Lopez , M Teresa Jaramillo

DOI: 10.1016/S0091-3057(03)00133-3

关键词:

摘要: The aim of the present study was to test hypothesis that allopregnanolone infused into lateral septal nuclei will reduce conflict-like behavior in ovariectomized rats. interaction with systemic administration several agonists and antagonists GABA-A receptor assessed. Results showed intralateral doses (1.0 μg, P<.05; 2.0 P<.05) or injections mg/kg sc, P<.05), diazepam (2.0 ip, muscimol (0.3 0.6 reduced behavior. Subthreshold infusions (0.5 μg/side) synergized subthreshold agonists: mg/kg, (1.5 (0.1 P<.05). antagonists, flumazenil ip) bicuculline attenuated synergism between muscimol, respectively. Conversely, neither (P<.05) nor combination (intralateral septum nuclei; 0.5 plus allopregnanolone. In conclusion, probably acting at receptors found nuclei.

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