Estradiol and neuropeptide Y (intra-lateral septal) reduce anxiety-like behavior in two animal models of anxiety
作者： Jorge I. Olivera-Lopez , Miguel Molina-Hernández , N. Patricia Tellez-Alcántara , M. Teresa Jaramillo
DOI: 10.1016/J.PEPTIDES.2008.04.002
关键词:
摘要: Anxiolytic-like effects of intra-lateral septal nuclei (LSN) infusions the neuropeptide Y (NPY) alone or combined with estradiol benzoate were assessed in ovariectomized Wistar rats two animal models anxiety-like behavior. In a conflict test, immediately punished responses assessed: 17-β-estradiol (50.0 μg/rat, P < 0.05) plus vehicle (intra-LSN) intra-LSN NPY (2.5 μg/μl, 0.05; 3.0 (systemic route) combination subthreshold doses (25.0 μg/kg) (2.0 increased amount reinforcers. elevated plus-maze test several spatial-temporal variables evaluated: μg/kg, produced anxiolytic-like actions without affecting locomotion. It is concluded that may produce and when actions.
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