Anticonflict Effect of Alpidem as Compared with the Benzodiazepine Alprazolam in Rats

摘要: A comparative study between two drugs acting on the GABAA receptor, alprazolam and alpidem was undertaken, using simple tests such as measurement of spontaneous locomotor activity, four plates test rotarod in mice. Additional conflict further performed a new paradigm where opportunity existed for rats to choose during punished periods immediate, reinforcement delayed non-punished reinforcement. The benzodiazepine alprazolam, demonstrated, expected, strong anxiolytic effects mice increased response at non sedative doses (0.5, 1 mg/kg). High decreased activity induced myorelaxant Alpidem, an imidazopyridine derivative, motor impairment only very weak (4 mg/kg) procedure (32 As is full agonist receptor complex partial with specificity ω1 subtypes, results are discussed. Activity subtypes perhaps not sufficient order obtain true anti-conflict effect compounds relieve some symptoms anxiety disorders.