High-potency benzodiazepines for short-term management of panic disorder: the U.S. experience.

摘要: Interest in benzodiazepines for treatment of panic attacks followed a report the success alprazolam, used generalized anxiety, blocking such attacks. Twelve controlled trials and several open studies have substantiated antipanic antiphobic activity alprazolam concluded it is comparable to but more rapid than antidepressants its effects better tolerated. In trial clonazepam, placebo, two active agents had similar positive effects. Diazepam lorazepam been effective other studies. Clonazepam, with relatively long half-life, permits less frequent dosing possible shorter half-lives continuous control although around 20% patients experience unacceptable sedative or no reduction anxiety. general, are safe well The most common adverse intoxication, dependence, rebound, withdrawal, hostility, affective disturbances. Discontinuation particularly difficult sometimes associated serious rebound withdrawal symptoms. morbidity mortality disorder suggest that benefits benzodiazepine outweigh risks.