Structure and serological characteristics of the capsular K4 antigen of Escherichia coli O5:K4:H4, a fructose-containing polysaccharide with a chondroitin backbone
作者： Maria-Luisa RODRIGUEZ , Barbara JANN , Klaus JANN
DOI: 10.1111/J.1432-1033.1988.TB14351.X-I2
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摘要: The chemical structure of the K4-specific capsular polysaccharide (K4 antigen) Escherichia coli O5:K4:H4 was elucidated by composition, carboxyl reduction periodate oxidation methylation nuclear-magnetic-resonance spectroscopy and enzymatic cleavage. consists a backbone with structure----3)-beta-D-glucuronyl-(1,4)-beta-D-N-acetylgalactosaminyl(1- to which beta-fructofuranose is linked at C-3 glucuronic acid. Mild acid hydrolysis liberated fructose converted K4 antigen into has same as chondroitin. defructosylated substrate for hyaluronidase chondroitinase. serological reactivity markedly reduced after defructosylation.
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