Roles of renal erythropoietin-producing (REP) cells in the maintenance of systemic oxygen homeostasis

摘要: Erythropoietic induction is critical for enhancing the efficiency of oxygen delivery during chronic phase systemic hypoxia response. The erythroid growth factor erythropoietin (Epo) triggers erythropoietic through activation genes related to cell survival, differentiation, and iron metabolism. Because Epo produced in renal Epo-producing (REP) cells a hypoxia-inducible manner, REP serve as control center In fact, loss production causes severe anemia genetically modified mice, cell-specific inactivation PHD2 (prolyl-hydroxylase domain enzyme 2) results erythrocytosis via overexpression gene due constitutive HIF2α (hypoxia-inducible transcription 2α). are located interstitial spaces between tubules capillaries, where supply low but consumption high, highly sensitive detection decreased supplies body. Under disease conditions, transform myofibroblasts lose their ability. Therefore, elucidation regulation features directly contributes understanding pathology kidney disease. To further analyze cells, we introduce newly established mouse line which efficiently labeled with fluorescent protein.