Cholinergic mechanisms mediating anesthetic induced altered states of consciousness.
作者： Steven B. Backman , Pierre Fiset , Gilles Plourde
DOI: 10.1016/S0079-6123(03)45014-0
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摘要: Publisher Summary A host of central neurotransmitter systems subserving γ-aminobutyric acid (GABA)ergic, glutamatergic, adrenergic, serotonergic, and cholinergic transmission are likely affected by anesthetics. Anesthetic drugs interfere with processes associated altered states consciousness. For example, administration opiates, halothane, isoflurane, enflurane decreased acetylcholine (ACh) release from neurones in the laterodorsal pedunculopontine tegmental (LDT/PPT) nuclei projecting to medial pontine reticular formation. Conversely, that directly affect activity also influence minimum alveolar concentration (MAC). There is one possibility general anesthetics produce unconsciousness. series experiments presented focuses on a hypothesis loss consciousness produced anesthetic involves depression, or indirectly, transmission. It was investigated whether physostigmine, centrally-acting anticholinesterase, reverses continuous drugs. In addition, it determined reversal blocked scopolamine, nonselective muscarinic antagonist.
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