Plasma prolidase activity: a possible index of collagen catabolism in chronic liver disease.

摘要: We describe here an easy method of determining prolidase (EC 3.4.13.9) in plasma after preincubation with Mn2+ for 24 h at 37 degrees C to maximize activity. The mean activity 338 patients who were either hospital or outpatients was 900 U/L +/- 520 (2 SD), unrelated sex age. In 25 these samples tested, between 1500 and 2000 U/L. It exceeded eight, all whom chronic liver disease. Plasma normal cytolytic syndromes such as heart Of the 27 cirrhosis, only five exhibited greater than uncorrelated six biochemical indexes function (the aminotransferases, alkaline phosphatase, glutamyltransferase, total bilirubin, serum albumin) degree cirrhotic fibrosis. believe that may be high early stage This hypothesis would consistent data on rat-liver collagenolytic activities during CCl4 administration. Monitoring might useful evaluating fibrotic processes disease human.