Initiation of Viral DNA Replication

摘要: Publisher Summary This chapter focuses on the mechanisms involved in initiation of animal virus DNA replication. step is fundamental importance because it represents central point control replication process. Two best-characterized viruses, adenovirus and SV40, are discussed as examples viruses that normally multiply by productive cytocidal infection. In these two cases viral begins soon after infection continues at a high rate until death host cell. other viruses—bovine papilloma Epstein-Barr virus—are presented capable multiplying stable extrachromosomal plasmids. precisely controlled so number genomes doubles only once per cell cycle under normal circumstances not killed. All groups described this chapter—as well most remaining (the poxviruses may constitute an exception)—initiate specific regions chromosome referred to origins There appears be little nucleotide sequence homology among various groups, although there some general structural features common many prokaryotic well. These include presence large palindromic sequences extensive A/T-rich blocks.