A tissue cage model in calves for studies on pharmacokinetic/pharmacodynamic interactions of antimicrobials.
作者： Christina Greko , Maria Finn , Patrik Öhagen , Anders Franklin , Björn Bengtsson
DOI: 10.1016/S0924-8579(03)00112-2
关键词:
摘要: An in vivo model for studies of pharmacokinetic/pharmacodynamic (PK/PD) interactions antimicrobials was developed. Tissue cages with a constant surface area but different volumes were implanted calves and infected Mannheimia haemolytica. Penicillin injected directly into the cages. With this procedure, concentration-time profiles could be simulated so that effect range PK/PD indices on infection monitored. The under curve to minimum inhibitory concentration (MIC) time above MIC equally predictive effect, Cmax not. If drug dosages relation strains used are optimised, offers an interesting alternative explore relevant factors dosage optimisation.
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