Antigenic variation in Trypanosoma brucei: facts, challenges and mysteries.
作者： Etienne Pays , Luc Vanhamme , David Pérez-Morga , None
DOI: 10.1016/J.MIB.2004.05.001
关键词:
摘要: Antigenic variation allows African trypanosomes to develop chronic infections in mammalian hosts. This process results from the alternative occurrence of transcriptional switching and DNA recombination targeted a telomeric locus that contains gene variant antigen is subjected mono-allelic expression control. So far, identification mechanisms factors involved still resists technological developments genome sequencing.
ulb.ac.be
core.ac.uk
elsevier.com
um.es 
sci-hub.se 参考文章(48)
G. Rudenko, P.A. Blundell, M.C. Taylor, R. Kieft, P. Borst, VSG gene expression site control in insect form Trypanosoma brucei. The EMBO Journal. ,vol. 13, pp. 5470- 5482 ,(1994) , 10.1002/J.1460-2075.1994.TB06882.X
J DAVIDBARRY, R MCCULLOCH, Antigenic variation in trypanosomes: enhanced phenotypic variation in a eukaryotic parasite. Advances in Parasitology. ,vol. 49, pp. 1- 70 ,(2001) , 10.1016/S0065-308X(01)49037-3
E. Pays, H. Coquelet, P. Tebabi, A. Pays, D. Jefferies, M. Steinert, E. Koenig, R. O. Williams, I. Roditi, Trypanosoma brucei: constitutive activity of the VSG and procyclin gene promoters. The EMBO Journal. ,vol. 9, pp. 3145- 3151 ,(1990) , 10.1002/J.1460-2075.1990.TB07512.X
H. M. Chung, C. Shea, S. Fields, R. N. Taub, L. H. Van der Ploeg, D. B. Tse, Architectural organization in the interphase nucleus of the protozoan Trypanosoma brucei: location of telomeres and mini-chromosomes. The EMBO Journal. ,vol. 9, pp. 2611- 2619 ,(1990) , 10.1002/J.1460-2075.1990.TB07443.X
C. E. Clayton, NEW EMBO MEMBER'S REVIEW Life without transcriptional control? From fly to man and back again The EMBO Journal. ,vol. 21, pp. 1881- 1888 ,(2002) , 10.1093/EMBOJ/21.8.1881
Patricia A Blundell, Piet Borst, Analysis of a variant surface glycoprotein gene expression site promoter of Trypanosoma brucei by remodelling the promoter region. Molecular and Biochemical Parasitology. ,vol. 94, pp. 67- 85 ,(1998) , 10.1016/S0166-6851(98)00051-6
H. Hecker, B. Betschart, K. Bender, M. Burri, W. Schlimme, The chromatin of trypanosomes. International Journal for Parasitology. ,vol. 24, pp. 809- 819 ,(1994) , 10.1016/0020-7519(94)90007-8
Luc Vanhamme, Magali Berberof, Dominique Le Ray, Etienne Pays, STIMULI OF DIFFERENTIATION REGULATE RNA ELONGATION IN THE TRANSCRIPTION UNITS FOR THE MAJOR STAGE-SPECIFIC ANTIGENS OF TRYPANOSOMA BRUCEI Nucleic Acids Research. ,vol. 23, pp. 1862- 1869 ,(1995) , 10.1093/NAR/23.11.1862
John E. Donelson, Antigenic variation and the African trypanosome genome Acta Tropica. ,vol. 85, pp. 391- 404 ,(2003) , 10.1016/S0001-706X(02)00237-1
Gloria Rudenko, Patricia A Blundell, Anita Dirks-Mulder, Rudo Kieft, Piet Borst, None, A ribosomal DNA promoter replacing the promoter of a telomeric VSG gene expression site can be efficiently switched on and off in T. brucei Cell. ,vol. 83, pp. 547- 553 ,(1995) , 10.1016/0092-8674(95)90094-2