Effect of ethanol consumption on the phospholipid composition of rat liver microsomes and mitochondria.

摘要: Male Sprague-Dawley rats were maintained for 31 days on a liquid diet containing 36% of calories as ethanol. Pair-fed controls administered similar diet, but with maltose-dextrin isocalorically substituted A phospholipid analysis has been carried out in liver microsomes and mitochondria isolated from the two groups animals. The phosphorus/protein ratio was not significantly different organelles ethanol-fed animals compared to same controls, which indicates that ethanol feeding did influence total content mitochondria. distribution within changed, except significant increase phosphatidylinositol fatty acid compositions both microsomal mitochondrial phospholipids altered by feeding. In rats, palmitic levels lowered fraction, phosphatidylcholine phosphatidylethanolamine; oleic elevated phosphatidylethanolamine. animals, arachidonic Oleic linoleic phospholipids. contrast, cardiolipin depressed significantly. These alterations composition are suggestive ethanol-induced changes desaturation activities.