Human cytomegalovirus immediate-early two protein region involved in negative regulation of the major immediate-early promoter
作者： T W Hermiston , C L Malone , M F Stinski
DOI: 10.1128/JVI.64.7.3532-3536.1990
关键词:
摘要: The immediate-early two (IE2) gene products of human cytomegalovirus negatively regulate expression from the major promoter in permissive fibroblasts. A mutational analysis IE2 proteins indicated that carboxyl-terminal region is required for negative regulation. lack amino acid residues 365 to 519, or acids failed regulate. Most amino-terminal portion protein was not possible explanation effect on downstream by discussed.
sci-hub.st 参考文章(45)
R M Stenberg, D R Thomsen, M F Stinski, Structural analysis of the major immediate early gene of human cytomegalovirus. Journal of Virology. ,vol. 49, pp. 190- 199 ,(1984) , 10.1128/JVI.49.1.190-199.1984
R M Stenberg, P R Witte, M F Stinski, Multiple spliced and unspliced transcripts from human cytomegalovirus immediate-early region 2 and evidence for a common initiation site within immediate-early region 1. Journal of Virology. ,vol. 56, pp. 665- 675 ,(1985) , 10.1128/JVI.56.3.665-675.1985
R M Stenberg, A S Depto, J Fortney, J A Nelson, Regulated expression of early and late RNAs and proteins from the human cytomegalovirus immediate-early gene region. Journal of Virology. ,vol. 63, pp. 2699- 2708 ,(1989) , 10.1128/JVI.63.6.2699-2708.1989
M F Stinski, Sequence of protein synthesis in cells infected by human cytomegalovirus: early and late virus-induced polypeptides. Journal of Virology. ,vol. 26, pp. 686- 701 ,(1978) , 10.1128/JVI.26.3.686-701.1978
A D Lakeman, J E Osborn, Size of infectious DNA from human and murine cytomegaloviruses. Journal of Virology. ,vol. 30, pp. 414- 416 ,(1979) , 10.1128/JVI.30.1.414-416.1979
P.A. Krieg, D.A. Melton, In vitro RNA synthesis with SP6 RNA polymerase. Methods in Enzymology. ,vol. 155, pp. 397- 415 ,(1987) , 10.1016/0076-6879(87)55027-3
C L Malone, D H Vesole, M F Stinski, Transactivation of a human cytomegalovirus early promoter by gene products from the immediate-early gene IE2 and augmentation by IE1: mutational analysis of the viral proteins. Journal of Virology. ,vol. 64, pp. 1498- 1506 ,(1990) , 10.1128/JVI.64.4.1498-1506.1990
P Ghazal, H Lubon, L Hennighausen, Specific interactions between transcription factors and the promoter-regulatory region of the human cytomegalovirus major immediate-early gene. Journal of Virology. ,vol. 62, pp. 1076- 1079 ,(1988) , 10.1128/JVI.62.3.1076-1079.1988
M W Wathen, D R Thomsen, M F Stinski, Temporal regulation of human cytomegalovirus transcription at immediate early and early times after infection. Journal of Virology. ,vol. 38, pp. 446- 459 ,(1981) , 10.1128/JVI.38.2.446-459.1981
A Fire, M Samuels, P A Sharp, Interactions between RNA polymerase II, factors, and template leading to accurate transcription. Journal of Biological Chemistry. ,vol. 259, pp. 2509- 2516 ,(1984) , 10.1016/S0021-9258(17)43382-5