CNS depressant and anticonvulsant activities of some novel 3-[5-substituted 1,3,4-thiadiazole-2-yl]-2-styryl quinazoline-4(3H)-ones

摘要: Abstract A series of new 3-[5-substituted phenyl-1,3,4-thiadiazole-2-yl]-2-styryl quinazoline-4(3 H )-ones were synthesized and evaluated for anticonvulsant, sedative–hypnotic CNS depression activities. After i.p. injection to mice or rat at doses 30, 100, 300 mg/kg body weight 2-styryl quinazolin-4(3 derivatives examined in the maximal electroshock (MES) induced seizures subcutaneous pentylenetetrazole (scPTZ) seizure models mice. Rotorod method was employed determine neurotoxicity. Out 18 compounds only 4a , 4e 4p showed anticonvulsant activity one more test models. All except 4l 4q exhibited significant via actophotometer screen. Forced swim pool depressant resulted some potent compounds. It can be concluded that better activities than activity.